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White Paper

Combining Biological Knowledge with Experimental Data

Target discovery is the most critical aspect of drug discovery. This whitepaper describes approaches in target identification and profiling, which combine new gene expression data with literature knowledge about potential protein and/or RNA interactions. It presents performance results from our initial explorations using commercial Bayesian network technology.

Finally, it explores some of the hard questions that teams refining these approaches must address, and suggests ways of scaling up the approach to today’s large data sets.

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