Oxford, UK | 14 June 2013.  Tessella, the international provider of science powered technology and consulting services and Berry Consultants, leaders in the Bayesian approach to medical statistics, are hosting a free online webinar for all life sciences professionals interested in the latest advances in Clinical Trial Design, Clinical Trial Simulation and Adaptive Clinical Trials.

Infectious diseases represent an area of high unmet medical need. However, trials in infectious diseases are typically costly and thus can be difficult to undertake. Experimental designs which reduce this cost while maintaining scientific validity are thus timely. Generally, there is a large amount of historical information available on antibiotic agents used in the control arm of such trials. We consider a hypothetical noninferiority trial of an experimental agent for the treatment of cUTI compared to Doripenem which utilizes historical information from two recent Doripenem studies. We discuss the possible advantages and disadvantages of using this historical information in our current trial. The proposed design is 20% smaller than a comparable fixed 1:1 design. In addition, due to unbalanced randomization, the proposed design actually allocates more subjects to treatment than the fixed design, while maintaining comparable power and type I error properties of the fixed design in a region centered around the historical point estimates.

Join Jeffrey Wetherington, Research Director, Statistics at GSK and Kert Viele of Berry Consultants on Tuesday 18th of June 2013 as they discuss Augmented Active Controls in A Novel Phase 3 Design Incorporating Historical Information for the Development of Antibacterial Agents.

Event Details:

Date:    Tuesday 18th of June 2013
Time:    3:00pm BST (10:00am EDT, 4:00pm CEST) for 1 hour plus open time for questions

Register to attend the webinar http://www.tessella.com/contact-us/other/register-for-the-webinar/

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Notes to the Editor

About Tessella
Founded in 1980, Tessella is the international provider of science powered technology and consulting services. World leading organisations choose our unique blend of science, engineering and sector expertise to deliver innovative and cost-effective solutions to complex real-world commercial and technical challenges. Our people are high achievers from leading universities and are passionate about delivering value to clients. We are proud that our work makes the world a better place to live in: developing smarter drug trials; preserving the digital heritage of nations across the globe; minimising risk in oil and gas exploration; controlling the orbit and attitude of satellites; researching fusion energy.

For further information visit www.tessella.com or visit our dedicated microsite on www.smarterclinicaltrials.com

About Berry Consultants
Berry Consultants is a statistical consulting group specializing in the Bayesian approach to medical statistics, an approach that is radically changing the way research is done throughout the medical industry in both device and drug development.  Berry Consultants employs world renowned experts in Bayesian statistics and strives to set the standard for innovative clinical trial design and analysis in the statistical and medical communities.

Further information is available at www.berryconsultants.com

Media Contact
Tessella | Christina Tealdi | Senior Marketing Communications and PR Manager
Phone: +44 (0) 1235 555511 | Mobile: + 44 (0) 779 9346453 | christina.tealdi@tessella.com

There was plenty of work to be done, but all staff members got stuck in with a great attitude. They helped with clearing and removing unwanted items, before setting to work repairing and restoring areas of the parks. They also added new play features, and planted new flowers to make the children’s areas even better places to spend time in.

The day was a huge success, plenty of fun was had by everyone involved and both co-ordinators at the sites commented on how the hard work put in by Tessella staff will have a great benefit on the local community.

As drug developers face intensifying pressure from generic drug firms, patent expirations, and increased scrutiny from the FDA, efficiency is more important than ever. The pharma and biopharma industry no longer approaches drug development alone, and after years of reduced R&D spending, numbers are on the rise. These dollars are increasingly being allocated to CROs. In their 2013 R&D Funding Forecast, R&D organization Battelle and R&D Magazine project that U.S. life science companies will increase R&D spending from $181.6 billion in 2012 to $189.3 billion in 2013…read more

Local government is increasingly dependent on digital channels to deliver current and future services cost effectively. The digital records these services generated are subject to the same statutory duties as paper ones, but unlike paper records, digital records are extremely vulnerable to changing technology. This puts organisations at risk from legal challenge and non-compliance. Preservica is a G-Cloud approved service that makes the long-term preservation of digital records easy and is available to local government from as little as £1,000 per month. Preservica is based on the system used by The National Archives.

Click on the link below to register for a Free Webinar to find out more: http://www.tessella.com/contact-us/stay-connected /register-for-the-gcloud-webinar/

What you will learn

• Why digital preservation is vital to Local Government Services
• How to make the business case for digital preservation in your organisation
• How G-Cloud iii makes procurement easy
• How Preservica synchronises with CALM
• Details of our “Early Adopter” promotional offer to UK Local Government

Event Details
Date: Tuesday 25th of June 2013
Time: 3:00pm BST for 45 minutes plus open time for questions

Who Should Attend
 Archivists – Librarians – Record Managers – Local Government Executives commissioning, delivering and operating digital services

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Notes to the Editor
About Digital Preservation at Tessella

Tessella is a world leader in digital preservation solutions, technology, consulting and research. Customers across 4 continents rely on our products to preserve their priceless digital information. Our solutions range from our cloud based Software as a Service offering, Preservica, to custom on premise installations of Tessella SDB. In 2011 Tessella and the UK National Archives won the Queen’s Award for Enterprise in the Innovation category for Tessella SDB the technology behind Preservica.

Find out about Preservica at www.preservica.com . Learn more about Digital Preservation and Tessella SDB at www.digital-preservation.com

Media Contact
Tessella
Christina Tealdi | Senior PR and Marketing Communications Manager
Phone: +44 (0) 1235 546638 | Mobile: +44 (0) 779 9346453 | christina.tealdi@tessella.com

Abstract:

Infectious diseases represent an area of high unmet medical need. However, trials in infectious diseases are typically costly and thus can be difficult to undertake. Experimental designs which reduce this cost while maintaining scientific validity are thus timely. Generally, there is a large amount of historical information available on antibiotic agents used in the control arm of such trials. We consider a hypothetical noninferiority trial of an experimental agent for the treatment of cUTI compared to Doripenem which utilizes historical information from two recent Doripenem studies. We discuss the possible advantages and disadvantages of using this historical information in our current trial. The proposed design is 20% smaller than a comparable fixed 1:1 design. In addition, due to unbalanced randomization, the proposed design actually allocates more subjects to treatment than the fixed design, while maintaining comparable power and type I error properties of the fixed design in a region centered around the historical point estimates.

Event Details:

• Date: Tuesday 18th of June
• Time: 3:00pm BST (10:00am EDT, 4:00pm CEST) for 1 hour plus open time for questions

Find Out More:

Register to listen to the webinar: http://www.tessella.com/contact-us/other/register-for-the-webinar/

Oxford, UK | 30th May 2013 | Tessella, the world leader in digital preservation has been accredited as a provider of Specialist Cloud Services under the UK Government Procurement Service G-Cloud framework for its digital preservation cloud based software as a service offering, Preservica. http://govstore.service.gov.uk/cloudstore/preservica.

Preserving digital records is one of the biggest challenges facing archives in the twenty-first century. Unlike paper records, which can last for hundreds of years in the right conditions, digital records are extremely vulnerable to changing technology.

Preservica runs on Amazon Web Services (AWS) and offers a long-term digital archiving and preservation system without the overheads of procuring a system or supporting the infrastructure. This cloud service is based on the world leading preservation system, Safety Deposit Box (SDB). Tessella and UK National Archives won the Queen’s Awards for Innovation in 2011. SDB has been adopted by archives and libraries all over the world.

Jon Tilbury, Tessella’s Director of Archiving Solutions, commented: “We are tremendously pleased that Preservica has been selected by the Government Procurement Service to be a supplier on the G-Cloud framework. Being part of the G- Cloud framework is clear evidence that the UK government is committed to leverage innovation through the diverse and valuable knowledge pool that sits within the SME’s across the UK. We look forward to engaging and working with a wide range of public sector bodies on some exciting projects.”

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Notes to the Editor

About Digital Preservation at Tessella
Tessella is world leader in digital preservation solutions, technology, consulting and research. Customers across 4 continents rely on our solution to preserve their priceless digital information. The solution is available on the cloud on a pay as you go plan with our Software as a Service offering, Preservica or as an on premise solution SDB. SDB, our core technology, now in its fourth generation, has won the UK’s Queen’s Award for Enterprise in the Innovation category. It provides a stable, professionally-supported platform with the flexibility to deliver individual customer needs.

Media Contact
Tessella
Christina Tealdi | Senior PR and Marketing Communications Manager
Phone: +44 (0) 1235 546638 | Mobile: +44 (0) 779 9346453 | christina.tealdi@tessella.com

A company in England is to design and develop essential controls that will help prevent one of the world’s most ambitious space missions from failing…read more

Washington, US | 21st May 2013

In 1996, it established the college archives and, in 2007, began to digitize parts of the collection primarily to widen access to the digitized records of student life past and present. Kelli Bogan, College Archivist, Colby-Sawyer College explains why: “When I started back in 2008, Colby-Sawyer had recently put in place a digitization project and digital archive.  One of my major roles was to digitize and digitally preserve our historically significant collections which included letters by Ralph Waldo

Emerson, American essayist, lecturer, and poet, and Susan Brownell Anthony, a prominent American civil rights leader along with student newspapers and college photos which were previously only accessible with an archives appointment during business hours.

The main goal was to make the archives more visible and a large part of the program was to make sure we are preserving the material that we digitized, making it accessible to students and alumni and to guarantee that we don’t have to do it all again 10 years down the line.”

However, Kelli grew increasingly concerned about the suitability of the content management system’s ability to manage the ever increasing volume of digital content and to preserve it for the long term.

Kelli continues: “I was getting more and more apprehensive that the system we had in place was not appropriate for long term digital preservation and not easy for students and alumni to access. For example, our system altered the dates that files were created and modified to the day they were entered into the system. We then looked at open-source digital preservation systems but found that the internal resource required to support such systems properly meant that it would not be cost effective for us.”

Kelli concludes: “Preservica is exactly what we were looking for because it’s a cost effective and production-ready solution to the challenges in the digital age.  We now feel safe in the knowledge that students and alumni alike can access digital records for many years to come.”

Jon Tilbury, Director of Archiving Solutions for Tessella commented: “We are very pleased that Colby-Sawyer selected Tessella’s Preservica.  It shows that having a world class digital preservation system is not only reserved for national archives and libraries.”

Jon continued: “Preservica really lowers the barriers to entry for organizations looking for full life cycle digital archiving and is suitable for commercial organizations or public institutions, in fact anyone who wants a high quality digital archiving system. Preservica is available via an affordable yearly subscription for the full application.”

Preservica is based on the advanced Safety Deposit Box (SDB) technology in use at leading National Archives and Libraries, making the same level of digital preservation service available to business, organizations, and memory institutions that need to protect their digital wealth without incurring all the human capital costs of running such a specialist service.

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Notes to the Editor

About Digital Preservation at Tessella

Tessella is world leader in digital preservation solutions, technology, consulting and research.  Customers across 4 continents rely on our on-premise solution, SDB, to preserve their priceless digital information.  The same world-leading solution is available in the cloud on a pay as you go plan with our Software as a Service offering, Preservica. Our core technology, now in its fourth generation, has won the UK’s Queen’s Award for Enterprise in the Innovation category.  It provides a stable, professionally-supported platform with the flexibility to deliver individual customer needs. 

Find out more about Preservica at our dedicated website www.preservica.com

Find out more about Digital Preservation visit www.digital-preservation.com

Media Contact

Tessella
Christina Tealdi | Senior PR and Marketing Communications Manager
Phone: +44 (0) 1235 546638 | Mobile: +44 (0) 779 9346453 | christina.tealdi@tessella.com